10 Best Cat Flea And Tick Preventions 2025 in the United States

Frontline Plus Flea and Tick Treatment for Cats is a popular option designed for cats weighing 1.5 pounds or more, including kittens from 8 weeks old. It combines two active ingredients, fipronil and (S)-methoprene, which work together to kill adult fleas, flea eggs, larvae, chewing lice, and ticks that can carry diseases like Lyme. This combination helps break the flea life cycle, reducing the chance of future infestations.

The Seresto Large Dog Flea & Tick Collar is a popular, vet-recommended option designed for dogs over 18 pounds. It uses active ingredients imidacloprid and flumethrin to kill and repel fleas and ticks by contact, so pests don't need to bite your dog for protection to work. This collar provides protection for up to 8 months, which means fewer treatments compared to monthly options. It's suitable for dogs as young as 7 weeks old, making it a flexible choice for both puppies and adult dogs.

PetArmor Plus Flea and Tick Prevention for Cats is a topical treatment designed for cats weighing over 1.5 pounds and aged 8 weeks or older. It contains the active ingredients fipronil and (s)-methoprene, which work together to kill fleas, flea eggs, larvae, ticks, and chewing lice. One of its strong points is that it helps break the flea life cycle, which means it doesn't just kill adult fleas but also prevents new infestations by targeting eggs and larvae. The formula is waterproof and fast-acting, starting to work within 24 hours and providing protection for up to 30 days per application. The pack includes 12 doses, enough to cover a full year of monthly treatment. It’s easy to apply by parting the cat’s fur at the shoulder blades and squeezing on the drops. Because the product can leave a greasy residue for about two days, you might need to clean the area gently if it seems excessive.